Jeffrey A. Kline, MD
Professor of Emergency Medicine and Physiology
Vice Chair, Research
Division Chief, Research
Editor in Chief, Academic Emergency Medicine
Office Location & Contact
Follow the Kline Lab
Carolinas Medical Center
Fellowship, Research, 1993
Residency, Emergency Medicine, 1993
Medical College of Virginia
MD, Class of 1990
Virginia Polytechnic Institute and State University
BS, Biochemistry, Class of 1986
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Dr. Kline's research fellowship and early research career focused on cardiac contractility and energy metabolism in shock states. This interest led Dr. Kline to focus on cardiopulmonary stress induced by severe pulmonary embolism. He developed and published a rat model of pulmonary embolism and subsequently began clinical studies using breath-based methods to diagnose and assess the severity of pulmonary embolism in humans. His research interest has expanded to include the development of breath-based devices to diagnose PE and computerized devices to predict pretest probability.
He has written 16 US patents for novel medical devices. To help translate these ideas into practice, he co-founded BreathQuant Medical Systems Inc, a privately held medical device company, currently supported by over $6.5MM in venture capital funding.
Over the past 7 years, he has published over 50 original manuscripts as first or senior author in the area of pulmonary embolism, and has trained 8 research fellows, all of whom hold faculty positions in emergency medicine.
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My primary research interest is pulmonary embolism (PE). My current largest main research project is a phase II clinical trial of inhaled nitric oxide to treat acute PE. T his trial has a translational laboratory component in which we are using blood from patients to test if intracardiac hemolysis contributes to pulmonary hypertension by scavenging nitric 1 oxide and activating platelets with PE. T he image shows the overview of the project.